Thomas ("Tom") Malone is the Founder and Chief Executive Officer at Precision TMS, with nearly three decades of experience in biomedical research and applying technology to improve healthcare. He is a former DOD researcher who utilized advanced neuroimaging techniques to visualize and study traumatic brain injury (TBI) and PTSD in military veterans. His main areas of expertise are neuroimaging, neuropsychological data analysis, traumatic brain injury (TBI), and post-traumatic stress disorder (PTSD), particularly among U.S. military veterans.

Tom earned his bachelor's degree in English Literature from the University of Missouri-St. Louis, completed graduate work in Neuroscience at Otto-von-Guericke University in Magdeburg, Germany as a visiting scientist, and holds an Executive MBA with an emphasis in International Business from Saint Louis University School of Business. He is CPR certified and has also earned his EMT license, which remains one of his favorite courses of study to date.

 

He has been the proud recipient of an American Heart Association Fellowship and has published in numerous journals over the years, including contributions to Tier 1 Journals such as Nature Neuroscience and PNAS.

 

He is past president and current board member of MEDLaunch, the biotech incubator at Saint Louis University School of Medicine, a founding member of the Acute Effects of Neurotrauma Consortium (AENC) at Ft. Leonard Wood, and is the co-founder of a medical device startup company. He is a member of the American College of Healthcare Executives (ACHE) and the Clinical TMS Society, where he serves as a member of the Business, Legal, and Ethics Committee.

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Selected Publications:

Cerebellar White Matter Abnormalities Following Primary Blast Injury in US Military Personnel.  C. Mac Donald, A. Johnson, D. Cooper, T. Malone, J. Sorrell, J. Shimony, M. Parsons, A. Snyder, M. Raichle, R. Fang, S. Flaherty, M. Russell, D. Brody. (2013). PLoS ONE 8(2): e55823. doi:10.1371/journal.pone.0055823

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Diffusion tensor imaging findings and neuropsychological performance in adults with TBI across the spectrum of severity in the chronic-phase. Zane KL, Gfeller JD, Roskos PT, Stout J, Buchanan TW, Malone TM, Bucholz R. Brain Inj. 2021 Apr 16;35(5):536-546. doi: 10.1080/02699052.2021.1887521. Epub 2021 Feb 17. PMID: 33593218.

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18F-FDG PET/CT Evidence of Hypothalamic and Pituitary Dysfunction in Depression, Anxiety, and PTSD-Like Symptoms among Post-Acute Veterans with Traumatic Brain Injury
T.M. Malone, O. Raslan, P. Kelly, D.M. Whitson, P.T. Roskos, R. Muzaffar, R.D. Bucholz, M. Osman. (Under Review)

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Diffusion Tensor Imaging in Post-Acute Blast Induced Traumatic Brain Injury and Associated Relationships to Neuropsychological Performance.

T.M. Malone, J. Bolzenius, M. Colijn, E. Schulze, P.T. Roskos, R.D. Bucholz, & J. Stout. (In preparation)

 

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Presentations:

Invited Speaker, Adaptive Training Foundation for Veterans with Disabilities at Emerge Fitness, St. Louis, MO Oct 2020

Invited Speaker, Brain Injury Association of Missouri, Annual Conference, St. Louis, MO, October, 2016

Invited Speaker, Department of the Army, Ft. Detrick, MD, Military Operational Medicine Research Program, June, 2016

Invited Speaker, North American Brain Injury Society (NABIS), Tampa, Florida, April, 2016

Invited Speaker, Department of Veterans Affairs, Jefferson Barracks, St. Louis, MO, April, 2016

Invited Speaker, Department of the Army, Ft. Leonard Wood TBI Symposium, Ft. Leonard Wood, MO, March, 2015

Invited Speaker, Radiological Society of North America (RSNA) Annual Conference, Chicago, IL, December, 2014

Keynote Speaker, Regional One Health, BIAA Annual Traumatic Brain Injury Conference, Memphis, TN, July, 2014

Invited Speaker, Radiological Society of North America (RSNA) Annual Conference, Chicago, IL, December, 2013

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Abstracts:

The value of 18F-FDG PET/CT in the Hypothalamic-Pituitary-Adrenal Axis in differentiation of blast-related mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) from blast-related mild TBI alone in a post-acute Veteran population.

Thomas M. Malone, Osama Raslan, Patrick Kelly, Diane M Whitson, P. Tyler Roskos, Razi Muzaffar, Richard Bucholz, Medhat Osman.

Radiological Society of North America (RSNA), Chicago, USA (Oral Presentation 12/1/2014).

 

Myelin Mapping of Traumatic Brain Injury Patients to Assess Physiological Mechanism for Neurological Deficits.

Manas Parikh, Thomas Malone, Randall Frausto, Jeffrey Stout, Richard Bucholz, P. Tyler Roskos.

Alpha Omega Alpha Medical Student Research Forum, Saint Louis University. January 9, 2014

 

Characterization of Fractional Anisotropy changes in blast-induced Traumatic Brain Injury using spatially registered Diffusion Tensor Imaging.

J. Stout, P. Roskos, J. Bolzenius, T. Malone, D. Mogul, R. Bucholz

Society for Neuroscience (SFN).

 

Diffusion Tensor Imaging in Post-Acute Blast Induced Traumatic Brain Injury and Associated Relationships to Neuropsychological Performance.

T.M. Malone, J. Bolzenius, M. Colijn, E. Schulze, P.T. Roskos, R.D. Bucholz, & J. Stout.

Radiological Society of North America (RSNA).

 

Utilization of 18F-FDG PET/CT to differentiate PTSD from TBI and the relationship of the hypothalamic-pituitary axis: initial experience.

Medhat M. Osman, Razi Muzaffar, Philip T. Roskos, Thomas M. Malone, Richard D. Bucholz.

 

Utility of the Community Integration Questionnaire to Assess Reintegration of Military Veterans with Traumatic Brain Injury. 

D. Whitson, T.M. Malone, S. Taylor, R. Bucholz, P.T. Roskos.

Submitted 4/2013 to North American Brain Injury Society (NABIS) conference.

 

Validation of the PTSD Checklist-Civilian Version in a Sample of Military Veterans and Civilians with Mild Traumatic Brain Injury.

Whitson, D., Salminen, L., Roskos, P.T., Malone, T.M., Gfeller, J.D. & Bucholz, R.D.

International Society for Traumatic Stress Studies (ISTSS) conference 2013.

 

Measuring social integration after mild traumatic brain injury among veterans using Community Integration Questionnaire (CIQ) and Glasgow Outcome Scale-Extended (GOSE).

S. D. Taylor, T.M. Malone, D. Whitson, W.R. Macneil, P.T. Roskos.

Pathways 2013 International Conference on Social Work in Health and Mental Health.

 

Early Prediction of Post-traumatic Stress Disorder Severity Following Blast-related Traumatic Brain Injury Using Advanced MRI-based Methods.

David L. Brody MD PhD1, Christine Mac Donald PhD1, Ann Johnson1, Toby Emanuel1, Tom Malone1, Dana Cooper1, Elliot Nelson MD1, Nicole Werner PhD1, Josh Shimony MD PhD1, Abraham Z. Snyder MD PhD1, Marcus Raichle MD1, COL (ret) Stephen Flaherty MD2 3 and Lt. Col Raymond Fang MD2

Advanced Technology Applications to Combat Casualty Care (ATACCC) Conference, 2011

 

English Title: Relationship between cortical and subcortical regions-a DTI study

Verbindungen zwischen kortikalen bzw. subkortikalen Regionen -eine DTI-Studie -

A. Osaba, U.Eckert, D. Horn, T.M. Malone, J. Kaufmann, B. Bogerts; M. Walter.

Abstract für die Mitteldeutschen Psychiatrietage in Dresden, 25.09-26.09.09.

 

Functional connectivity in the Default Mode Network at rest is related to its neurotransmitter patterns -

A combined fMRI/MRS approach in healthy humans and depressive patients.

D.I. Horn, J. Buchmann, J. Kaufmann, A. Osaba, U. Eckert, T. M. Malone, J. Steiner, B. Biswal, B. Bogerts, M. Walter.

Society for Neuroscience, Chicago, USA, October, 2009

 

English Title: Representation of structural changes in cortico-subcortical connectivity in depressed

patients. Darstellung veränderter kortiko-subkortikaler struktureller Konnektivität bei depressiven

Patienten.

A.Osoba, U.Eckert, D.Horn, T.M. Malone, J.Kaufmann, B.Bogerts, M.Walter.

DGPPN-Kongress, 25. – 28. November 2009, Berlin.

 

English Title: Functional magnetic resonance imaging at rest and magnetic resonance spectroscopy in patients with affective disorders.

Funktionelle Magnetresonanztomographie im Ruhezustand und Magnetresonanzspektroskopie bei Patienten mit affektiven Erkrankungen.

Horn D.I., Buchmann J., Osoba A., Kaufmann J., Eckert U., Malone T.M., Biswal B., Bogerts B., Walter M.

Mitteldeutsche Psychiatrietage, Dresden, 25. – 26 September 2009

 

Resting State functional MRI and MR-Spectroscopy in Major Depressive Disorder – Preliminary results.

D Horn, J Buchmann, J Kaufman, U Eckert, T.M. Malone, Y Kim, B Biswal, B Bogerts, M Walter.

9th World Congress of Biological Psychiatry, 28th June – 2nd July 2009, Paris, France

 

English Title: Altered Resting state functional connectivity is associated with specific metabolic patterns. - A combined fMRI / MRS examination in healthy subjects and depressed patients.

Veränderte funktionelle Resting State Konnektivität geht mit spezifischen metabolischen Mustern einher. – Eine kombinierte fMRT/MRS Betrachtung bei Gesunden und depressiven Patienten.

D.I. Horn, J. Buchmann, J. Kaufmann, A. Osoba, U. Eckert, T.M. Malone, J.Steiner, B. Biswal, B. Bogerts, M.Walter

DGPPN-Kongress, 25. – 28. November 2009, Berlin

 

A Comparison of Different Methods for Identifying Outliers in MRS Data.

S.B. Hall, M. Popescu, A. Popescu, N. Nazir, T.M. Malone, R. Aupperle, A. Schmitt, J. Lierman, W. M. Brooks

Joint Statistical Meetings, August 5-10, 2006, Seattle, Washington, USA.

 

Brain Volume and Cognition in Traumatic Brain Injury.

R. Mummeneni, J. Burns, T.M. Malone, W.M. Brooks.

University of Kansas Medical Center, Department of Neurology, Residents’ Research Day Award – First Place Winner.

 

Traumatic Brain Injury: 3 Tesla Magnetic Resonance Spectroscopic Imaging and Cognitive Function. W. M. Brooks, C. Savage, R. Aupperle, T. M. Malone, A. Schmitt, J. Lierman, A. Popescu, M. Popescu.

International Society for Magnetic Resonance in Medicine, February, 2004.

 

Magnetic Resonance Spectroscopic Imaging is Sensitive to Severity in Traumatic Brain Injury.

W.M. Brooks, S.B. Hall, J. Lierman, A.L. Schmitt, L.R. Ladesich, T.M. Malone, R.L. Aupperle, C.R. Savage

Proc. Of the 14th Meeting of the Intl. Soc. Mag. Reson. Med., May 6-12, 2006, Seattle, Washington, USA.

 

Traumatic Brain Injury: 3 Tesla Magnetic Resonance Spectroscopic Imaging and Cognitive Function.

Brooks, W.M., Savage, C., Aupperle, R., Malone, T.M., Schmitt, A., Lierman, J., Popescu, M.

Proc.Of the 13th Meeting of the Intl. Soc. Mag. Reson. Med., May 7-13, 2005. Miami, Florida, USA.